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Article

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.

Retrovirology - 10 Sept 2020

Millen Sebastian, Meretuk Lina, Göttlicher Tim, Schmitt Sarah, Fleckenstein Bernhard, Thoma-Kress Andrea K

Abstract excerpt

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region (Tax) is important for initiating malignant transformation, and deregulation of the major signaling pathway nuclear factor...

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Identifiers

PMID: 32912211
DOI: 10.1186/s12977-020-00538-w
PMCID: PMC7488018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.PMID 32912211Read ↗

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