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Article

A multi-omics approach reveals specific oncogenic and inflammatory potential of viral oncoproteins Tax from neglected HTLV-1b and -1c genotypes.

PLoS pathogens - 1 Aug 2026

Duchateau Thomas, Bongers Alice, Abdelmoumen Karim, Rey Carine, Dussurgey Sébastien, Brocard Jacques, Gerardin Dalia, Béziat Marie-Lou, Lormières Florence, Bhat Devashish, Guillon Christophe, Gouet Patrice, Afonso Philippe V, Journo Chloé

Abstract excerpt

Over the recent years, reports of very high prevalence of Human T-cell Leukemia Virus (HTLV) type 1 genotype c infection in remote aboriginal populations in Central Australia have sparked a renewed interest in the genetic variability of this human oncogenic retrovirus. While clinical and epidemiological studies suggest that HTLV-1 genotypes might be associated with varying risks of pathological manifestations,...

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Topics

Human T-lymphotropic virus 1
Humans
Gene Products, tax
Jurkat Cells
HTLV-I Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

NF-kappa B

Inflammation

Source

Open in PubMed Open full text

Identifiers

PMID: 42640959
DOI: 10.1371/journal.ppat.1014512
PMCID: PMC13537692

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