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Article

Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells.

Experimental cell research - 15 Jan 2003

Ewald Jonathan A, Wilkinson John C, Guyer Cheryl A, Staros James V

Abstract excerpt

To investigate the intrinsic activities of the epidermal growth factor receptor and the role of its kinase domain in these functions within a cellular environment lacking endogenous ErbB protein expression, wild-type EGF receptor (WT-EGFR) and two kinase-impaired mutants, D813A and K721R, were expressed in 32D murine hematopoietic cells, a line which is normally dependent on interleukin 3 (IL3) for growth and...

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Source

Identifiers

PMID: 12531698
DOI: 10.1016/s0014-4827(02)00014-9

Genes

EGF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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