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Article

p53-induced inhibition of protein synthesis is independent of apoptosis.

European journal of biochemistry - 1 Aug 2003

Constantinou Constantina, Bushell Martin, Jeffrey Ian W, Tilleray Vivienne, West Matthew, Frost Victoria, Hensold Jack, Clemens Michael J

Abstract excerpt

Activation of a temperature-sensitive form of p53 in murine erythroleukaemia cells results in a rapid impairment of protein synthesis that precedes inhibition of cell proliferation and loss of cell viability by several hours. The inhibition of translation is associated with specific cleavages of polypeptide chain initiation factors eIF4GI and eIF4B, a phenomenon previously observed in cells induced to undergo...

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Identifiers

PMID: 12869187
DOI: 10.1046/j.1432-1033.2003.03687.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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