Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

6 Aug 1996

Abstract excerpt

The insulin-like growth factor I receptor (IGF-I-R) plays a critical role in transformation events. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Tumor suppressor p53 is a nuclear transcription factor that blocks cell cycle progression and induces apoptosis. p53 is the most frequently mutated gene in human cancer. Cotransfection of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Growth Hormone and Insulin-like Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8710868
DOI: 10.1073/pnas.93.16.8318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.PMID 8710868Read ↗

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection PathwaysSemantic proximity Read ↗

p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells.Semantic proximity Read ↗

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.Semantic proximity Read ↗

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.Semantic proximity Read ↗

Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249.Semantic proximity Read ↗

The C Terminus of p53 Family Proteins Is a Cell Fate DeterminantSemantic proximity Read ↗

The SV40 Large T Antigen-p53 Complexes Bind and Activate the Insulin-like Growth Factor-I Promoter Stimulating Cell GrowthSemantic proximity Read ↗

Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.Semantic proximity Read ↗

The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.Semantic proximity Read ↗

Role of insulin-like growth factor 1 receptor signalling in cancerSemantic proximity Read ↗

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.Semantic proximity Read ↗

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.