Article
Failure of T cell receptor V beta negative selection in murine intestinal intra-epithelial lymphocytes.
International immunology - 1 Oct 1991
Murosaki S, Yoshikai Y, Ishida A, Nakamura T, Matsuzaki G, Takimoto H, Yuuki H, Nomoto K
Abstract excerpt
The intestinal intra-epithelial lymphocytes (IEL) are divided into several subsets on the basis of expression of T cell receptor (TCR) alpha beta and gamma delta, intensity of Thy-1 expression and expression of Lyt-3 chain. To investigate the differentiation pathway of the IEL, we examined the repertoire of V beta segments of T cells in the IEL in BALB/c (H-2d, MIs-1b2a) or AKR/J (H-2k, MIs-1a2b) mice. Among...
Topics
- Animals
- Antigens, CD
- CD4 Antigens
- CD8 Antigens
- Epithelium
- Female
- Flow Cytometry
- Gene Expression
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Liver
- Mice