Association of -158 (C-->T) (XmnI) DNA polymorphism in G gamma-globin promoter with delayed switchover from fetal to adult hemoglobin synthesis.

doi:10.1203/00006450-199702000-00010

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Article

Association of -158 (C-->T) (XmnI) DNA polymorphism in G gamma-globin promoter with delayed switchover from fetal to adult hemoglobin synthesis.

Pediatric research - 1 Feb 1997

Peri K G, Gagnon J, Gagnon C, Bard H

Abstract excerpt

In this study, the effect of -158 (C-->T) (XmnI) polymorphism on the synthesis of fetal Hb and its G gamma component during the switchover from fetal to adult Hb was examined using cord blood samples from normal Caucasian term infants. The presence of -158(C-->T) mutation was determined by amplif...

Topics

Adult
Fetal Blood
Fetal Hemoglobin
Gestational Age
Globins
Hemoglobins
Humans
Infant, Newborn
Mutation
Polymorphism, Genetic
Promoter Regions, Genetic

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