A new type of hereditary persistence of fetal haemoglobin (HPFH): HPFH Tunisia beta + (+C-200)G gamma.

Article

A new type of hereditary persistence of fetal haemoglobin (HPFH): HPFH Tunisia beta + (+C-200)G gamma.

British journal of haematology - 1 Oct 1996

Pissard S, M'rad A, Beuzard Y, Roméo P H

Abstract excerpt

Nd-HPFH are haematological conditions which are natural models to aid understanding of the haemoglobin (Hb) switch. In this paper we describe a new non-deletional hereditary persistence of fetal haemoglobin (nd-HPFH) associated with the highest Hb F level observed to date (up to 49% without haemo...

Topics

Consanguinity
DNA Transposable Elements
Female
Fetal Hemoglobin
Hemoglobinopathies
Heterozygote
Homozygote
Humans
Male
Mutation
Pedigree
Promoter Regions, Genetic
Sequence Analysis, DNA

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