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Article

Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin.

Blood - 1 Oct 2004

Garner Chad, Silver Nicholas, Best Steve, Menzel Stephan, Martin Charlotte, Spector Tim D, Thein Swee Lay

Abstract excerpt

The switch from fetal to adult hemoglobin is incomplete; the residual fetal hemoglobin in adults is restricted to a subset of erythrocytes called F cells. F-cell levels are influenced by a sequence variant (C-->T) at position -158 upstream of the gamma-globin gene, termed the XmnI-Ggamma polymorphism. How the Ggamma-158 C-->T variant influences the expression of the Ggamma-globin gene is unknown but is likely to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15205260
DOI: 10.1182/blood-2004-02-0527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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