Article
Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.
The EMBO journal - 1 Jun 1990
Jardetzky T S, Gorga J C, Busch R, Rothbard J, Strominger J L, Wiley D C
Abstract excerpt
Major histocompatibility complex (MHC) glycoproteins play an important role in the development of an effective immune response. An important MHC function is the ability to bind and present 'processed antigens' (peptides) to T cells. We show here that the purified human class II MHC molecule, HLA-DR1, binds peptides that have been shown to be immunogenic in vivo. Detergent-solubilized HLA-DR1 and a papain-cleaved...
Topics
- Alanine
- Amino Acid Sequence
- Animals
- HLA-DR1 Antigen
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Humans
- Influenza A virus
- Kinetics
- Molecular Sequence Data
- Mutation