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Article

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

The EMBO journal - 1 Jun 1990

Jardetzky T S, Gorga J C, Busch R, Rothbard J, Strominger J L, Wiley D C

Abstract excerpt

Major histocompatibility complex (MHC) glycoproteins play an important role in the development of an effective immune response. An important MHC function is the ability to bind and present 'processed antigens' (peptides) to T cells. We show here that the purified human class II MHC molecule, HLA-DR1, binds peptides that have been shown to be immunogenic in vivo. Detergent-solubilized HLA-DR1 and a papain-cleaved...

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Identifiers

PMID: 2189723
DOI: 10.1002/j.1460-2075.1990.tb08304.x
PMCID: PMC551884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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