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Article

Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?

Immunogenetics - 1 Aug 2015

van Deutekom Hanneke W M, Keşmir Can

Abstract excerpt

Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all polymorphic residues are located in the peptide-binding groove, resulting in different peptide-binding preferences. Whether a single amino acid change can alter the peptide-binding repertoire of an HLA molecule has never been shown. To experimentally quantify the contribution of a single amino acid change to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26040913
DOI: 10.1007/s00251-015-0849-y
PMCID: PMC4498290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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