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Article

Multivariant confirmation of sickle cell disease using a non-radioactive minisequencing reaction.

Hemoglobin - 1 Jan 1997

Tuuminen T, Ingman H, Therrell B L, Kallio A

Abstract excerpt

A non-radioactive solid-phase minisequencing method for confirmation of abnormal hemoglobin variants causing sickle cell disease has been developed. In this method amplified 5'-biotinylated target sequences containing normal and mutation sites are immobilized onto streptavidin-coated microplates. Detection primers corresponding to target sequences are annealed immediately adjacent to the mutation site and...

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Share to Anemia, Sickle Cell
Share to Diagnosis, Differential
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemoglobins, Abnormal

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Share to Polymerase Chain Reaction

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Source

Identifiers

PMID: 9028825
DOI: 10.3109/03630269708997512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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