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Article

Multiplex minisequencing screen for common Southeast Asian and Indian beta-thalassemia mutations.

Clinical chemistry - 1 Feb 2003

Wang Wen, Kham Shirley K Y, Yeo Gare-Hoon, Quah Thuan-Chong, Chong Samuel S

Abstract excerpt

BACKGROUND: Beta-thalassemia is endemic to many regions in Southeast Asia and India, and <20 beta-globin gene mutations account for > or =90% of beta-thalassemia alleles in these places. We describe a multiplex minisequencing assay to detect these common mutations. METHODS: Gap-PCR was used to simultaneously amplify the beta-globin gene from genomic DNA and to detect the Delta619bp deletion mutation. Multiplex...

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PMID: 12560342
DOI: 10.1373/49.2.209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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