Article
Physiological and genetic characterization of the Gly40Ser mutation in the glucagon receptor gene in the Sardinian population. The Sardinian Diabetes Genetic Study Group.
Diabetologia - 1 Jan 1997
Tonolo G, Melis M G, Ciccarese M, Secchi G, Atzeni M M, Maioli M, Pala G, Massidda A, Manai M, Pilosu R M, Li L S, Luthman H, Maioli M
Abstract excerpt
A Gly40Ser amino acid substitution in the glucagon receptor gene has been associated with non-insulin-dependent diabetes mellitus (NIDDM), but the questions raised about its physiological implications have not been resolved. The aim of this study was to determine the frequency of the Gly40Ser mutation in different regions of Sardinia and to investigate the physiological implications of the mutation in glucose and...
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