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Article

GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.

Metabolism: clinical and experimental - 1 Mar 2005

Ogawa Takeo, Hirose Hiroshi, Miyashita Kiichi, Saito Ikuo, Saruta Takao

Abstract excerpt

GPR40 is a member of the G-protein-coupled receptors. Recent studies suggest that GPR40 is highly expressed in pancreatic beta cells and insulin-secreting cell lines, and that fatty acids increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion by activating GPR40. Despite identification of the Arg211His polymorphism in the GPR40 gene, there have been no clinical studies...

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PMID: 15736105
DOI: 10.1016/j.metabol.2004.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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