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Article

Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 1999

Brand E, Bankir L, Plouin P F, Soubrier F

Abstract excerpt

A missense mutation (Gly40Ser) in exon 2 of the glucagon receptor gene (GCG-R) was shown to reduce ligand affinity and impair cAMP response. We conducted a case-control study with a sample of 741 French hypertensive patients with moderate to severe hypertension and 412 normotensive control subjects, who were genotyped for this biallelic variant by use of hybridization with allele-specific oligonucleotides. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10406817
DOI: 10.1161/01.hyp.34.1.15

Genes

GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study.PMID 10406817Read ↗

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