Article
Glucagon receptor Gly40Ser amino acid variant in Sardinian hypertensive non-insulin-dependent diabetic patients. Sardinian Diabetic Genetic Study Group (SDGSG).
Acta diabetologica - 1 Aug 1997
Tonolo G, Melis M G, Ciccarese M, Secchi G, Atzeni M M, Li L S, Luthman H, Maioli M
Abstract excerpt
A significantly different prevalence in the Gly40Ser variant of the glucagon receptor gene in a small group of essential hypertensive patients compared with normotensive probands was described in a Caucasian population. It has been postulated that this variant may exacerbate the antinatriuretic effect of high plasma insulin levels commonly seen in hypertensive subjects, leading to volume expansion and rise in...
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