Article
Transcriptional regulation of the human chromogranin A gene by its 5' distal regulatory element: novel effects of orientation, structure, flanking sequences, and position on expression.
Molecular and cellular endocrinology - 29 Nov 1996
Nolan E M, Cheung T C, Burton D W, Deftos L J
Abstract excerpt
In previous studies of human chromogranin A (hCgA) gene expression, we had identified a 27 bp distal regulatory element (DRE) located between -576 and -550 bp that interacts with a CRE-containing promoter to enhance gene transcription specifically in neuroendocrine (NE) cells. To characterize the...
Topics
- Base Sequence
- Cell Line
- Chromogranin A
- Chromogranins
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes
- Humans
- Molecular Sequence Data
- Mutation
- Neurosecretory Systems
- Nuclear Proteins
- Oligonucleotides
- Promoter Regions, Genetic