Identification and characterization of a neuroendocrine-specific 5'-regulatory region of the human chromogranin A gene.

doi:10.1210/endo.136.12.7588318

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Article

Identification and characterization of a neuroendocrine-specific 5'-regulatory region of the human chromogranin A gene.

Endocrinology - 1 Dec 1995

Nolan E M, Cheung T C, Burton D W, Deftos L J

Abstract excerpt

Chromogranin A (CgA) expression is specific to cells of endocrine and neuroendocrine (NE) tissues. Our transfection studies with CgA have identified two DNA regions 5' of the transcription start site that regulate CgA gene transcription: a distal regulatory region (DRR) located between -726 and -...

Topics

Base Sequence
Chromogranin A
Chromogranins
Gene Expression Regulation
Genes, Regulator
Humans
Molecular Sequence Data
Mutation
Transfection
Tumor Cells, Cultured

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