Article
Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1996
Seo H, Yang C, Kim H S, Kim K S
Abstract excerpt
The dopamine beta-hydroxylase (DBH) gene is expressed selectively in noradrenergic and adrenergic neurons and neuroendocrine cells in the nervous system. A cAMP response element (CRE) residing at -181 to -174 bp from the transcription start site of the human DBH gene seems to be essential for DBH...
Topics
- Base Sequence
- Cyclic AMP Response Element-Binding Protein
- DNA Footprinting
- DNA-Binding Proteins
- Dopamine beta-Hydroxylase
- Erythroid-Specific DNA-Binding Factors
- Genes
- Genes, Regulator
- HeLa Cells
- Humans