Article
Neuroendocrine cell type-specific and inducible expression of the chromogranin B gene: crucial role of the proximal promoter.
Endocrinology - 1 Oct 2000
Mahapatra N R, Mahata M, Datta A K, Gerdes H H, Huttner W B, O'Connor D T, Mahata S K
Abstract excerpt
Chromogranin B, a soluble acidic secretory protein, is widely distributed in neuroendocrine and neuronal cells, although not in other cell types. To identify the elements governing such widespread, yet selective, expression of the gene, we characterized the isolated mouse chromogranin B promoter. 5'-Promoter deletions localized neuroendocrine cell type-specific expression to the proximal chromogranin B promoter...
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