Article
Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2005
Kam Kyung-Yoon, Jeong Kyeong-Hoon, Norwitz Errol R, Jorgensen Elisa M, Kaiser Ursula B
Abstract excerpt
The cis-regulatory element localized to position -292/-285 of the mouse GnRH receptor (mGnRHR) gene promoter, designated Sequence Underlying Responsiveness to GnRH 1 (SURG-1), has been shown previously to contribute to stimulation of mGnRHR gene expression by GnRH. We have identified three specific protein-DNA complexes on the SURG-1 element by EMSA using nuclear extracts from the gonadotrope-derived alphaT3-1...
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