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Article

Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma.

Molecular carcinogenesis - 1 Jan 1997

Kleymenova E V, Bianchi A A, Kley N, Pylev L N, Walker C L

Abstract excerpt

The neurofibromatosis 2 (NF2) tumor suppressor gene was recently implicated in the genesis of human mesothelioma. To investigate the role of this tumor suppressor gene in rat asbestos-induced mesothelioma, a commonly used model for the human disease, we characterized the rat homologue of NF2 and examined rat chrysotile-induced primary mesotheliomas and cell lines derived from chrysotile- and crocidolite-induced...

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PMID: 9022813

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