Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma.

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Article

Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma.

Molecular carcinogenesis - 1 Jan 1997

Kleymenova E V, Bianchi A A, Kley N, Pylev L N, Walker C L

Abstract excerpt

The neurofibromatosis 2 (NF2) tumor suppressor gene was recently implicated in the genesis of human mesothelioma. To investigate the role of this tumor suppressor gene in rat asbestos-induced mesothelioma, a commonly used model for the human disease, we characterized the rat homologue of NF2 and...

Topics

Animals
Asbestos
Base Sequence
Blotting, Northern
DNA
Genes, Neurofibromatosis 2
Humans
Mesothelioma
Molecular Sequence Data
Mutation
Peritoneal Neoplasms
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
RNA Splicing
Rats
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9022813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9022813-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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