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Article

A conditional mouse model for malignant mesothelioma.

Cancer cell - 1 Mar 2008

Jongsma Johan, van Montfort Erwin, Vooijs Marc, Zevenhoven John, Krimpenfort Paul, van der Valk Martin, van de Vijver Marc, Berns Anton

Abstract excerpt

Malignant mesothelioma is a devastating disease that has been associated with loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB and P53 pathways. We introduced similar lesions in the mesothelial lining of the thoracic cavity of mice. Mesothelioma developed at high incidence in Nf2;Ink4a/Arf and Nf2;p53 conditional knockout mice with median survival times of approximately 30 and 20 weeks,...

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Identifiers

PMID: 18328429
DOI: 10.1016/j.ccr.2008.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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