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Article

Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours.

Oncogene - 12 Jun 2003

Fleury-Feith Jocelyne, Lecomte Céline, Renier Annie, Matrat Mireille, Kheuang Laurence, Abramowski Vincent, Levy Françoise, Janin Anne, Giovannini Marco, Jaurand Marie-Claude

Abstract excerpt

Biallelic NF2 gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether NF2 hemizygosity may enhance susceptibility to asbestos fibres, we investigated the Nf2 status in mesothelioma developed in mice presenting a heterozygous mutation of the Nf2 gene (Nf2(KO3/+)), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed Nf2(KO3/+) mice developed tumoural...

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Identifiers

PMID: 12802287
DOI: 10.1038/sj.onc.1206593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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