Article
Transgenic mice bearing the polyomavirus large T antigen directed by 2.1 kb of the keratin 19 promoter develop bronchiolar papillary tumors with progression to lung adenocarcinomas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1995
Lebel M, Webster M, Muller W J, Royal A, Gauthier J, Mes-Masson A M
Abstract excerpt
Keratin 19 is an intermediate filament protein produced by cells of simple epithelia and basal cells of stratified epithelia of different organs. These cell types are associated with important human cancers. We have used the keratin 19 promoter to target the expression of the polyomavirus (Py) la...
Topics
- Adenocarcinoma
- Animals
- Antigens, Polyomavirus Transforming
- Bronchi
- Cell Line
- Culture Techniques
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Keratins
- Lung Neoplasms
- Mice
- Mice, Inbred Strains
- Mice, Transgenic