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Article

Differentiation versus proliferation of transgenic mouse lens cells expressing polyoma large T antigen: evidence for regulation by an endogenous growth factor.

The New biologist - 1 Aug 1990

Griep A E, Westphal H

Abstract excerpt

Expression of the immortalizing oncogene polyoma large T antigen (PyLT) in the lens of transgenic mice impairs fiber cell differentiation but does not induce hyperplasia or tumor development. To examine this phenotype further, we studied the expression of the lens-specific crystallin genes in normal mice and mice of the transgenic alpha PyLT1 lineage. Immunochemical analyses showed that the spatial pattern of...

Topics

Animals
Antigens, Polyomavirus Transforming
Cell Differentiation
Cell Division
Crystallins
Epithelium
Fluorescent Antibody Technique
Gene Expression
Genotype
Lens, Crystalline
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Phenotype

Polyomavirus

Source

Identifiers

PMID: 2178003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2178003-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Differentiation versus proliferation of transgenic mouse lens cells expressing polyoma large T antigen: evidence for regulation by an endogenous growth factor.PMID 2178003Read ↗

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