Article
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
Cancer research - 1 May 2003
Brembeck Felix H, Schreiber Franz S, Deramaudt Therese B, Craig Linden, Rhoades Ben, Swain Gary, Grippo Paul, Stoffers Doris A, Silberg Debra G, Rustgi Anil K
Abstract excerpt
A frequent genetic alteration found in premalignant stages of pancreatic adenocarcinoma is K-ras oncogene point mutation. The mechanistic basis for the inability of K-ras mutation to transform pancreatic ductal cells is unclear, although cooperating events with p16 inactivation, p53 mutation, and...
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