Article
The HPV 16 genome induces carcinomas and T-cell lymphomas in transgenic mice.
The American journal of pathology - 1 Jul 1995
Yang J T, Liu C Z, Iannaccone P
Abstract excerpt
Human papillomavirus type 16 is highly associated with cervical carcinoma. Here we report families of transgenic mice produced by the microinjection of a dimer repeat sequence of the human papillomavirus type 16 genome. Thirty-two transgenic animals in four families developed multiple organ malignancies that appeared in middle age without other intervention. The tumor phenotype of poorly differentiated carcinomas...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Carcinoma
- DNA Primers
- DNA, Viral
- Female
- Genome, Viral
- Immunoenzyme Techniques
- Lymphoma, T-Cell
- Male
- Mice