Article
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice.
Journal of virology - 1 Jul 1994
Arbeit J M, Münger K, Howley P M, Hanahan D
Abstract excerpt
To model human papillomavirus-induced neoplastic progression, expression of the early region of human papillomavirus type 16 (HPV16) was targeted to the basal cells of the squamous epithelium in transgenic mice, using a human keratin 14 (K14) enhancer/promoter. Twenty-one transgenic founder mice...
Topics
- Animals
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Division
- Ear
- Filaggrin Proteins
- Keratins
- Mice
- Mice, Transgenic
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins
- Phenotype
- Precancerous Conditions
- Promoter Regions, Genetic
- RNA, Viral
- Skin
- Skin Neoplasms