Article
Distribution of apolipoprotein E gene polymorphisms in Japanese patients with Alzheimer's disease and in Japanese centenarians.
Human heredity - 1 Jan 2000
Yamagata Z, Asada T, Kinoshita A, Zhang Y, Asaka A
Abstract excerpt
We have demonstrated an association between apolipoprotein E (apoE) gene polymorphisms and Alzheimer's disease (AD) in 163 Japanese patients by means of PCR. We found a significant increase in risk of nonfamilial AD for apoE allele epsilon4 in these individuals; this trend decreases with the increase in onset age. In centenarians, the distribution of apoE gene alleles is similar to that in the general population....
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