Article
Rapid detection of apolipoprotein E genotypes in Alzheimer's disease using polymerase chain reaction-single strand conformation polymorphism.
The Southeast Asian journal of tropical medicine and public health - 1 Jul 2006
Kamruecha Worawan, Chansirikarnjana Sirintorn, Nimkulrat Ekapot, Udommongkol Chesda, Wongmek Wanna, Thangnipon Wipawan
Abstract excerpt
Apolipoprotein E (APOE) gene on chromosome 19q13.2 is encoded by three common alleles designated as epsilon2, epsilon3 and epsilon4. In Alzheimer's disease (AD) the epsilon4 allele is over-represented and is considered to be a major genetic risk factor. Several methods have been developed to dete...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Female
- Gene Frequency
- Genetic Techniques
- Genotype
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational