HLA-DR, DQ and anti-GAD antibodies in first degree relatives of type I diabetes mellitus.

doi:10.1016/s0168-8227(96)01316-2

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Article

HLA-DR, DQ and anti-GAD antibodies in first degree relatives of type I diabetes mellitus.

Diabetes research and clinical practice - 1 Oct 1996

Serrano-Ríos M, Gutierrez-López M D, Pérez-Bravo F, Martínez M T, Antona J, Rowley M, Mackay I, Zimmet P

Abstract excerpt

The differential antibody response to glutamic acid decarboxylase (anti-GAD) and to islet cell cytoplasm (ICA) according to HLA-DR and DQ genotypes were examined in 28 Spanish patients with Type I diabetes mellitus (11.1 +/- 10.4 year diabetes duration) and their 41 first degree non-diabetic relatives. Anti-GAD was detected by radioimmunoprecipitation and ICA by indirect immunofluorescence and HLA-DR/DQ alleles...

Topics

Adolescent
Adult
Alleles
Animals
Biomarkers
Child
Child, Preschool
Diabetes Mellitus, Type 1
Family
Female
Genotype
Glutamate Decarboxylase
HLA-DQ Antigens
HLA-DR Antigens
Humans

Source

Open in PubMed

Identifiers

PMID: 9015682
DOI: 10.1016/s0168-8227(96)01316-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Immune Sera

Islets of Langerhans

Male