Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.

Abstract excerpt

Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit a wide range of throat abnormalities. In addition, they often feature defects of the heart and...

Topics

• Abnormalities, Multiple
• Animals
• Animals, Newborn
• Arteries
• Bone and Bones
• Cartilage
• Embryonic and Fetal Development
• Esophagus
• Gene Expression
• Genes, Homeobox
• Heart Defects, Congenital