Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2002

Ren Shu-Yue, Angrand Pierre-Olivier, Rijli Filippo M

Abstract excerpt

Recent studies indicated that retention of selectable marker cassettes in targeted Hox loci may cause unexpected phenotypes in mutant mice, due to neighborhood effects. However, the molecular mechanisms have been poorly investigated. Here, we analysed the effects of the targeted insertion of a PGK-neo cassette in the 3' untranslated region of Hoxa2. Even at this 3' position, the insertion resulted in homozygous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Nucleotidyltransferases
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrases

Share to Neomycin

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Rhombencephalon

Share to RNA Splicing

Share to Transcriptional Activation

Source

Identifiers

PMID: 12412013
DOI: 10.1002/dvdy.10171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression.PMID 12412013Read ↗

A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination.Semantic proximity Read ↗

Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish.Semantic proximity Read ↗

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells.Semantic proximity Read ↗

Different levels of Hoxa2 are required for particular developmental processes.Semantic proximity Read ↗

Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects.Semantic proximity Read ↗

Zebrafish hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch.Semantic proximity Read ↗

Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family.Semantic proximity Read ↗

Generation and expression of a Hoxa11eGFP targeted allele in mice.Semantic proximity Read ↗

Targeted disruption of the <i>Hoxb-2</i> locus in mice interferes with expression of <i>Hoxb-1</i> and <i>Hoxb-4</i>Semantic proximity Read ↗

Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression.Semantic proximity Read ↗

Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function.Semantic proximity Read ↗

[Functional analysis of mouse Hox genes by gene targeting].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.