Article
Acquired fusion activity of a murine coronavirus MHV-2 variant with mutations in the proteolytic cleavage site and the signal sequence of the S protein.
Virology - 6 Jan 1997
Yamada Y K, Takimoto K, Yabe M, Taguchi F
Abstract excerpt
The spike (S) protein of a nonfusogenic murine coronavirus, MHV-2, was compared to the S protein of a variant with fusion activity, MHV-2f. Two amino acids differed between the S proteins of these viruses; one was located in the signal sequence and the other was in the putative cleavage site. The...
Topics
- Binding Sites
- Biological Transport
- Cell Line
- Cytopathogenic Effect, Viral
- Giant Cells
- Membrane Fusion
- Membrane Glycoproteins
- Molecular Sequence Data
- Murine hepatitis virus
- Mutation
- Protein Sorting Signals
- Spike Glycoprotein, Coronavirus
- Trypsin
- Viral Envelope Proteins