Article
Role of basic residues in the proteolytic activation of Sendai virus fusion glycoprotein.
Virus research - 1 Apr 1995
Heminaway B R, Yang Y, Tanaka Y, Panin M, Huang Y T, Galinski M S
Abstract excerpt
Cleavage activation of the Sendai virus (Fushimi strain) fusion (F) protein was analyzed by site-directed mutagenesis of the amino acids proximal to the highly conserved fusion peptide. In addition, the functional properties of the wild-type and mutant proteins were examined to determine their ability to elicit the formation of syncytia when co-expressed with the hemagglutinin-neuraminidase (HN) glycoprotein....
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Giant Cells
- HN Protein
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Parainfluenza Virus 1, Human