Article
The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years.
Journal of medical genetics - 1 Dec 1996
Tysoe C, Robinson D, Brayne C, Dening T, Paykel E S, Huppert F A, Rubinsztein D C
Abstract excerpt
The genetic factors that predispose to Alzheimer's disease (AD) are heterogeneous. Two recent reports have suggested that a mitochondrial DNA mutation within the tRNAGln gene, located at position 4336, may be a risk factor for AD, as it was found in 10/256 (3.9%) cases with AD confirmed by necrop...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cognition
- DNA, Mitochondrial
- Dementia
- Female
- Genetic Variation
- Humans
- Longitudinal Studies
- Male