Article

Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

2019-01-22

Abstract excerpt

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a method for simulating relatives that can utilize either sex-specific or sex averaged genetic maps and also either a model...

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Literature Corpus work: 1d2761a4-d9d8-5f76-a99b-8cfbeefc29f6
DOI: 10.1101/527655

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