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Article

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Molecular and cellular biology - 1 Feb 1997

Kohlhuber F, Rogers N C, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn B A, Kotenko S V, Pestka S, Stark G R, Ihle J N, Kerr I M

Abstract excerpt

Cell lines that are mutated in interferon (IFN) responses have been critical in establishing an essential role for the JAK family of nonreceptor tyrosine kinases in interferon signalling. Mutant gamma1A cells have previously been shown to be complemented by overexpression of JAK2. Here, it is shown that these cells carry a defect in, and can also be complemented by, the beta-subunit of the IFN-gamma receptor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9001223
DOI: 10.1128/MCB.17.2.695
PMCID: PMC231795

Genes

JAK2
JAK1
STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.PMID 9001223Read ↗

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.Semantic proximity Read ↗

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.Semantic proximity Read ↗

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.Semantic proximity Read ↗

JAKs, STATs and signal transduction in response to the interferons and other cytokinesSemantic proximity Read ↗

Shared receptor components but distinct complexes for alpha and beta interferons.Semantic proximity Read ↗

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.Semantic proximity Read ↗

Jak2 is essential for signaling through a variety of cytokine receptors.Semantic proximity Read ↗

The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signalsSemantic proximity Read ↗

Signaling through a mutant IFN-gamma receptor.Semantic proximity Read ↗

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.Semantic proximity Read ↗

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.Semantic proximity Read ↗

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.Semantic proximity Read ↗

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