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Article

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

Molecular and cellular biology - 1 Apr 1997

Li X, Leung S, Kerr I M, Stark G R

Abstract excerpt

Two members of the STAT signal transducer and activator of transcription family, STAT1 and STAT2, are rapidly phosphorylated on tyrosine in response to alpha interferon (IFN-alpha). Previous work showed that in the mutant human cell line U6A, which lacks STAT2 and is completely defective in IFN-alpha signaling, the phosphorylation of STAT1 is very weak, revealing that activation of STAT1 depends on STAT2. We now...

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Identifiers

PMID: 9121453
DOI: 10.1128/MCB.17.4.2048
PMCID: PMC232052

Genes

STAT2
STAT1
IFNAR1
IFNAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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