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Article

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.

Chemistry & biology - 25 Mar 2011

Haan Claude, Rolvering Catherine, Raulf Friedrich, Kapp Manuela, Drückes Peter, Thoma Gebhard, Behrmann Iris, Zerwes Hans-Günter

Abstract excerpt

Genetic deficiency of Jak3 leads to abrogation of signal transduction through the common gamma chain (γc) and thus to immunodeficiency suggesting that specific inhibition of Jak3 kinase may result in immunosuppression. Jak1 cooperates with Jak3 in signaling through γc-containing receptors. Unexpectedly, a Jak3-selective inhibitor was less efficient in abolishing STAT5 phosphorylation than pan-Jak inhibitors. We...

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Source

Identifiers

PMID: 21439476
DOI: 10.1016/j.chembiol.2011.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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