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Article

Regulation of the activity of the type IC EcoR124I restriction enzyme.

Journal of molecular biology - 20 Dec 1996

Kulik E M, Bickle T A

Abstract excerpt

Restriction-modification (R-M) systems must regulate the expression of their genes so that the chromosomal genome is modified at all times by the methyltransferase to protect the host cell from the potential lethal action of the cognate restriction endonuclease. Since type I R-M systems can be transferred to non-modified Escherichia coli cells by conjugation or transformation without killing the recipient, they...

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Identifiers

PMID: 9000619
DOI: 10.1006/jmbi.1996.0685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the activity of the type IC EcoR124I restriction enzyme.PMID 9000619Read ↗

The effect of recA mutation on the expression of EcoKI and EcoR124I hsd genes cloned in a multicopy plasmid.Semantic proximity Read ↗

A deletion mutant of the type IC restriction endonuclease EcoR1241 expressing a novel DNA specificity.Semantic proximity Read ↗

A novel mutant of the type I restriction-modification enzyme EcoR124I is altered at a key stage of the subunit assembly pathway.Semantic proximity Read ↗

Restriction endonucleases R.EcoKI and R.EcoR124I are probably located in different environments within the bacterial cell.Semantic proximity Read ↗

Target recognition by EcoKI: the recognition domain is robust and restriction-deficiency commonly results from the proteolytic control of enzyme activity.Semantic proximity Read ↗

Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes.Semantic proximity Read ↗

Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA.Semantic proximity Read ↗

Isolation of a non-classical mutant of the DNA recognition subunit of the type I restriction endonuclease R.EcoR124I.Semantic proximity Read ↗

A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I.Semantic proximity Read ↗

Plasmid-encoded antirestriction protein ArdA can discriminate between type I methyltransferase and complete restriction-modification system.Semantic proximity Read ↗

Maintenance forced by a restriction-modification system can be modulated by a region in its modification enzyme not essential for methyltransferase activity.Semantic proximity Read ↗

The restriction-modification genes of Escherichia coli K-12 may not be selfish: they do not resist loss and are readily replaced by alleles conferring different specificities.Semantic proximity Read ↗

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