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Article

Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 1999

Makovets S, Doronina V A, Murray N E

Abstract excerpt

ClpXP-dependent proteolysis has been implicated in the delayed detection of restriction activity after the acquisition of the genes (hsdR, hsdM, and hsdS) that specify EcoKI and EcoAI, representatives of two families of type I restriction and modification (R-M) systems. Modification, once established, has been assumed to provide adequate protection against a resident restriction system. However, unmodified...

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Source

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Identifiers

PMID: 10449767
DOI: 10.1073/pnas.96.17.9757
PMCID: PMC22283

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes.PMID 10449767Read ↗

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