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Article

Reovirus σ1 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment.

Journal of virology - 9 Nov 2020

Diller Julia R, Halloran Sean R, Koehler Melanie, Dos Santos Natividade Rita, Alsteens David, Stehle Thilo, Dermody Terence S, Ogden Kristen M

Abstract excerpt

Reovirus attachment protein σ1 is a trimeric molecule containing tail, body, and head domains. During infection, σ1 engages sialylated glycans and junctional adhesion molecule-A (JAM-A), triggering uptake into the endocytic compartment, where virions are proteolytically converted to infectious subvirion particles (ISVPs). Further disassembly allows σ1 release and escape of transcriptionally active reovirus cores...

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Share to Capsid Proteins
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cell Surface

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Identifiers

PMID: 32938765
DOI: 10.1128/JVI.01163-20
PMCID: PMC7654274

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