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Article

Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant.

Journal of virology - 1 Nov 1998

Rodgers S E, Connolly J L, Chappell J D, Dermody T S

Abstract excerpt

The reovirus sigma1s protein is a 14-kDa nonstructural protein encoded by the S1 gene segment. The S1 gene has been linked to many properties of reovirus, including virulence and induction of apoptosis. Although the function of sigma1s is not known, the sigma1s open reading frame is conserved in all S1 gene sequences determined to date. In this study, we identified and characterized a variant of type 3 reovirus,...

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Identifiers

PMID: 9765398
DOI: 10.1128/JVI.72.11.8597-8604.1998
PMCID: PMC110270

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