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Article

Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.

Molecular and cellular biology - 1 Oct 2018

Shen Yong, Bassett MacLean A, Gurumurthy Aishwarya, Nar Rukiye, Knudson Isaac J, Guy Cameron R, Perez Alex, Mellen Russell W, Ikeda Masatoshi, Hossain Mir A, Huang Suming, Igarashi Kazuhiko, Bungert Jörg

Abstract excerpt

The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid cell development, with the embryonic ε-globin gene being located at the 5' end, followed by the two fetal γ-globin genes, and with the adult β- and δ-globin genes being located at the 3' end. Here, we functionally characterized a DNase I-hypersensitive site (HS) located 4 kb upstream of the...

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Identifiers

PMID: 30012865
DOI: 10.1128/MCB.00197-18
PMCID: PMC6146835

Genes

EGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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