Article
Functional significance of polymorphism among MHC class II gene promoters.
Tissue antigens - 1 Dec 1996
Guardiola J, Maffei A, Lauster R, Mitchison N A, Accolla R S, Sartoris S
Abstract excerpt
The functional significance of polymorphism among MHC class II promoters in man and mouse is here reviewed, mainly in terms of the hypothesis of differential expression. The hypothesis proposes that differences between antigen-presenting cells in MHC class II expression exert a co-dominant effect on the Th1-Th2 cytokine balance, such that class II molecules of one type come to control to a greater extent the...
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