Article
The genetic analysis of lacI mutations in sectored plaques from Big Blue transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1996
Stuart G R, Gorelick N J, Andrews J L, de Boer J G, Glickman B W
Abstract excerpt
The Big Blue lacI transgenic rodent assay, which uses the lambda LIZ/lacI gene as the target for mutation, provides a convenient short-term assay for the study of mutation in vivo [Kohler et al. (1991): Proc Natl Acad Sci USA 88:7958-7962; Provost et al. (1993): Mutat Res 288:133-149). However, the interpretation of data from transgenic animal assays is sometimes complicated by mutants that appear as sectored...
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