Article
Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue Rat2 embryonic fibroblasts.
Mutagenesis - 1 Sept 1998
Watson D E, Cunningham M L, Tindall K R
Abstract excerpt
Big Blue Rat2 embryonic fibroblasts carry the lambda-Liz shuttle vector which is also present in the Big Blue mouse and rat. Mutations in the Big Blue systems have most often been measured at the lacI locus. However, a method for positive selection of mutations at the lambda cII locus was recentl...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Bacterial Proteins
- Bacteriophage lambda
- Base Sequence
- CpG Islands
- DNA Adducts
- DNA Damage
- DNA Mutational Analysis
- DNA, Recombinant
- Escherichia coli Proteins
- Ethylnitrosourea
- Fibroblasts
- Frameshift Mutation
- Genes, Viral
- Genetic Vectors
- Lac Operon