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Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue Rat2 embryonic fibroblasts.

Mutagenesis - 1 Sept 1998

Watson D E, Cunningham M L, Tindall K R

Abstract excerpt

Big Blue Rat2 embryonic fibroblasts carry the lambda-Liz shuttle vector which is also present in the Big Blue mouse and rat. Mutations in the Big Blue systems have most often been measured at the lacI locus. However, a method for positive selection of mutations at the lambda cII locus was recently described. This assay appears to have many advantages over the use of lacI as a mutational target, but it has yet to...

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PMID: 9800194
DOI: 10.1093/mutage/13.5.487

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